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目的研究血清C反应蛋白(CRP)测定在晚期胃癌患者中的临床意义。方法对102例经过病理确诊的晚期胃癌患者的血清CRP水平进行检测,同时检测癌胚抗原(CEA),糖类抗原19-9(CA19-9),并对治疗前后的CRP、CEA、CA19-9水平进行对比分析。结果 CRP在胃癌中数值明显升高,经过治疗后,患者的CRP水平均较治疗前有明显的下降,差异有统计学意义(P<0.05)。CA19-9、CEA和CRP联合检测阳性率较单独肿瘤标志物检测阳性率明显升高。结论 CRP对胃癌诊断及预后判断有临床价值,与CEA、CA19-9结合起来可以作为胃癌诊断治疗的标记物。
Objective To study the clinical significance of serum C-reactive protein (CRP) in patients with advanced gastric cancer. Methods The serum levels of CRP in 102 patients with pathologically diagnosed advanced gastric cancer were detected. CEA and CA19-9 were also detected. The levels of CRP, CEA, CA19 - 9 levels for comparative analysis. Results The value of CRP in gastric cancer was significantly increased. After treatment, the CRP level in patients with CRP was significantly lower than that before treatment (P <0.05). The positive rate of combined detection of CA19-9, CEA and CRP was significantly higher than that of tumor marker alone. Conclusion CRP has clinical value in the diagnosis and prognosis of gastric cancer. Combined with CEA and CA19-9, CRP can be used as a marker for the diagnosis and treatment of gastric cancer.