Analysis of bacitracin and its related substances by liquid chromatography tandem mass spectrometry

• 作 者: Suleiman Ahmed Suleiman Fan So
• 机 构: DepartmentofPharmaceuticalAnalysis
• 出 处: 药物分析学报：英文版
• 发表日期: 2017年1期
• 关键词: BACITRACIN DEGRADATION products FRAGMENTATION PATHWAYS Related substances LC–Q-T
• 基金项目: financially supported by both the National Natural Science Foundation (NO. 81402900),,the Fundamental Research Funds for the Central Universities of the Ministry of Education (NO. 2015PT043) of China

A suitable liquid chromatography quadrupole time-of-flight mass spectrometric (LC-Q-TOF-MS) method wasdeveloped for separation and characterization of related substances in bacitracin test drug. The separation wasperformed on LiChrospher RP-18 column usin