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肿瘤细胞引起多样性和易突变性很难直接用药物治疗,并且肿瘤细胞的耐药性也已成为治疗的一个瓶颈。靶向肿瘤血管的抗体治疗通过靶向实体肿瘤内血管内皮细胞生长增殖的相关靶点,切断肿瘤细胞的营养供应从而达到治疗肿瘤的目的。本文中总结了近年来世界各国已上市或处于临床阶段及实验室阶段的靶向肿瘤血管抗体药物,并阐述了该治疗策略的特点及部分抗体药物的作用机制,提出目前存在的问题和相关解决方法,为靶向肿瘤血管的抗体治疗研究提供一定的参考。
Tumor cells cause diversity and mutation is difficult to direct drug treatment, and tumor cell resistance has also become a bottleneck in the treatment. Antibody therapy targeting tumor vasculature aims to treat tumors by cutting off the nutrient supply of tumor cells by targeting related targets of growth and proliferation of vascular endothelial cells in solid tumors. This article summarizes the targeted tumor vasoactive drugs that are listed or in the clinical and laboratory stages in various countries in the world in recent years, and expounds the characteristics of the therapeutic strategy and the mechanism of action of some of the antibody drugs, and presents the existing problems and related solutions Method for the treatment of tumor vascular targeting antibody research to provide some reference.