论文部分内容阅读
目的探讨氯沙坦联合吲哒帕胺对老年高血压患者的血压、血尿酸(UA)及血、尿β2-微球蛋白(β2-MG)的影响。方法50例老年高血压患者随机分成两组,对照组(吲哒帕胺组)24例,观察组(氯沙坦加吲哒帕胺组)26例,观察12 w,比较治疗前后患者血压、血钾、血UA及血、尿β2-MG等指标的变化。结果治疗后两组收缩压及舒张压均较治疗前明显下降(P<0.01),两组比较无差异(P>0.05);对照组治疗前后比较,血UA浓度明显升高(P<0.01),血、尿β2-MG浓度无明显变化,血钾明显降低(P<0.05),观察组治疗前后血UA及血、尿β2-MG均明显下降(P<0.01)。结论吲哒帕胺和氯沙坦联合治疗老年高血压病,较单独用药更有效地控制血压,降低血UA及减少低血钾的发生,保护靶器官,具有良好的安全性和耐受性。
Objective To investigate the effects of losartan plus indapamide on blood pressure, serum uric acid (UA), blood and urine β2-microglobulin (β2-MG) in elderly patients with hypertension. Methods Fifty elderly patients with hypertension were randomly divided into two groups: control group (indapamide group) 24 cases, observation group (losartan plus indapamide group) 26 cases, observed for 12 weeks, compared before and after treatment of patients with blood pressure, Serum potassium, blood UA and blood, urine β2-MG and other indicators of change. Results The systolic blood pressure and diastolic blood pressure of the two groups were significantly decreased after treatment (P <0.01), but there was no difference between the two groups (P> 0.05). The UA concentration in the control group was significantly increased before and after treatment (P <0.01) , Blood and urine β2-MG concentration had no significant change, serum potassium decreased significantly (P <0.05). Before and after treatment, blood UA and blood and urine β2-MG were significantly decreased (P <0.01). Conclusion Indapamide and losartan combined treatment of elderly patients with hypertension, compared with single drug more effective in controlling blood pressure, lower blood UA and reduce the incidence of hypokalemia, protect the target organ, with good safety and tolerability.