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目的观察盐酸法舒地尔对急性脑梗死患者血清超敏C反应蛋白和血管内皮生长因子的影响。方法 86例急性脑梗死患者随机分为两组,治疗组46例,对照组40例。对照组采用常规治疗,治疗组在常规治疗基础上加用法舒地尔,共观察21 d。治疗前后测定血清超敏C反应蛋白(hs-CRP)和血管内皮生长因子(VEGF)。结果两组在治疗7、21 d后神经功能均有明显好转,并且治疗组改善程度在7、21 d均优于对照组(P<0.05)。两组在治疗后hs-CRP和VEGF均有显著降低,并且治疗组降低程度更明显(P<0.05)。结论法舒地尔可以减少急性脑梗死患者hs-CRP和VEGF的表达,从而改善病情。
Objective To observe the effect of fasudil hydrochloride on serum high sensitive C-reactive protein and vascular endothelial growth factor in patients with acute cerebral infarction. Methods A total of 86 patients with acute cerebral infarction were randomly divided into two groups: treatment group (46 cases) and control group (40 cases). The control group was treated routinely, and the treatment group was given fasudil on the basis of routine treatment for a total of 21 days. Serum high sensitivity C-reactive protein (hs-CRP) and vascular endothelial growth factor (VEGF) were measured before and after treatment. Results The neurological function of both groups improved obviously after 7 and 21 days of treatment, and the improvement of the treatment group was better than that of the control group on 7 and 21 days (P <0.05). The hs-CRP and VEGF in both groups were significantly decreased after treatment, and the treatment group decreased more significantly (P <0.05). Conclusion fasudil can reduce the expression of hs-CRP and VEGF in patients with acute cerebral infarction, thereby improving the condition.