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目的 探讨上皮细胞黏附分子 E-钙黏着素 (E-CD)和 β-连接素 (β-CA)在贲门癌的表达及其与肿瘤生物学行为的关系。方法 应用免疫组化 S-P法检测 78例贲门癌组织标本中钙黏着素 E和β-连接素在贲门癌中的表达。结果 贲门癌组织中 E-CD、β-CA的异常表达率分别为 47.4%和 62 .8% ,均与贲门癌瘤体大小、生长方式、分化程度、浸润深度和 TNM分期密切相关 (P<0 .0 5或 P<0 .0 1)。前者与淋巴结转移密切相关 (P<0 .0 1) ,后者与之无关 (P>0 .0 5)。弥漫型比肠型贲门癌 E-CD、β-CA的异常表达率明显升高 (P<0 .0 1)。结论 E-CD和 β-CA对贲门癌的生长、浸润和转移有促进作用 ,E-CD和β-CA可作为反映贲门癌生物学行为的指标
Objective To investigate the expression of E-cadherin (E-CD) and β-catenin (β-CA) in epithelial cell carcinoma of the cardia and its relationship with tumor biological behavior. Methods The expressions of cadherin E and β-catenin in cardiac carcinoma of cardia were detected by immunohistochemical S-P method in 78 cases of cardia cancer. Results The abnormal expression rates of E-CD and β-CA in cardia cancer tissues were 47.4% and 62.8%, respectively, which were closely related to the size, growth pattern, differentiation degree, infiltration depth and TNM stage of gastric cardia carcinoma (P < 0 .0 5 or P <0 .0 1). The former was closely related to lymph node metastasis (P <0.01), while the latter had no relation (P> 0.05). The abnormal expression of E-CD and β-CA in diffuse type was significantly higher than that of type Ⅱcarcinoma (P <0.01). Conclusions E-CD and β-CA can promote the growth, infiltration and metastasis of cardia cancer, E-CD and β-CA can be used as indicators of biological behavior of cardia cancer