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目的：探讨特利加压素在脓毒血症难治性休克中的临床使用价值，为今后的临床工作提供借鉴。方法我院于2013年1月至2014年1月期间，共收治50例脓毒血症休克患者，其中17例患者使用多巴胺及去甲肾上腺素疗效不佳，对该17例患者，给予特利加压素进行治疗，并观察给药后患者的各个指标的变化。结果使用特利加压素之后，患者的休克指数下降明显，且平均动脉压显著上升，尿量和心率也在给药12小时后改善明显。结论特利加压素可显著改善脓毒血症难治性休克患者的临床症状和各项指标，患者获益明显，临床应用价值较高。“,”Objective: To investigate the terlipressin in treatment of intractable septic shock in clinicaluse value, provide reference for future clinical work. Methods: in our hospital from 2013 January tO2014 January, there were 50 cases of septic shock patients, including 17 cases of patients withdopamine and norepinephrine poor efficacy, of the 17 patients, giving terlipressin for treatment, andto observe the change of patients after administration of each index. Results: after the use ofterlipressin, patients with shock index decreased significantly, and the mean arterial pressureincreased, urine volume and heart rate at 12 hours after administration improved significantly.Conclusion: terlipressin can significantly improve the clinical symptoms in treatment of intractable septic shock patients and indicators, with significant benefits, the higher the value of clinical application.