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银屑病是一种免疫性疾病，大量研究证实 T细胞在其发生、发展中起重要作用。近年来，传统药物治疗银屑病的疗效不高、不良反应大，而生物制剂表现出显著的疗效和较好的安全性。靶向性生物制剂能阻断T细胞活化及其相关细胞因子的产生，在治疗中、重度银屑病方面疗效显著。近年来国外应用生物制剂治疗银屑病的报道屡见不鲜，国内虽有使用，但甚少。该文对多种银屑病生物制剂的作用机制、临床疗效和国内病例报道进行了综述。“,”Psoriasis is an autoimmune disease,and numerous studies have confirmed that T cell plays an important role in its occurrence.The efficacy of the traditional medicine for treating psoriasis is not high ,and it has some adverse reactions.Biological agent showed significant effect and good safety in the treatment of psoriasis in recent years.Targeted biologics can block the activation of T cell and related cytokines,which have shown good to excellent clinical outcomes for psoriasis.In recent years,the application of biological agents to treat psoriasis has been frequently reported abroad.Although there are also being used in China,but little. Here reviews the mechanism,clinical efficacy and domestic case reports of biological agents for psoriasis.