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目的:观察转化生长因子-β1(TGF-β1)在宫颈鳞状细胞癌组织中的表达情况,探讨其与宫颈癌发生发展的关系,明确其表达的意义。方法:应用免疫组化SP法检测40例宫颈鳞状细胞癌组织(病理分级Ⅰ~Ⅲ级)中TGF-β1蛋白的表达,与正常宫颈组织及慢性宫颈炎组织中的表达作定量比较。结果:①正常宫颈组织及慢性宫颈炎组织中TGF-β1表达位于上皮细胞的胞浆内,两组表达水平无显著性差异(P>0.05);宫颈鳞状细胞癌中TGF-β1表达位于癌细胞的胞浆内。②宫颈鳞状细胞癌中TGF-β1表达水平明显上升,与正常宫颈组织及慢性宫颈炎组织比较有极显著性差异(P<0.01)。③随着宫颈癌病理分级的增加,TGF-β1表达水平逐步上升,有显著性差异(P<0.05)。结论:本研究提示宫颈鳞状细胞癌的发生发展可能与TGF-β1的高表达有关。
OBJECTIVE: To observe the expression of transforming growth factor-β1 (TGF-β1) in cervical squamous cell carcinoma and to explore the relationship between the expression of TGF-β1 and the occurrence and development of cervical carcinoma. Methods: The expression of TGF-β1 protein in 40 cases of cervical squamous cell carcinoma tissues (pathological grade Ⅰ ~ Ⅲ grade) was detected by immunohistochemical SP method and compared with the expression in normal cervical tissues and chronic cervicitis tissues. Results: ① The expression of TGF-β1 in normal cervical tissue and chronic cervicitis was located in the cytoplasm of epithelial cells with no significant difference (P> 0.05). The expression of TGF-β1 in cervical squamous cell carcinoma Intracellular cytoplasm of cells. ② The expression of TGF-β1 in squamous cell carcinoma of the cervix was significantly increased compared with that in normal cervix and chronic cervicitis (P <0.01). ③ With the increase of pathological grade of cervical cancer, the expression of TGF-β1 gradually increased, with significant difference (P <0.05). Conclusion: This study suggests that the occurrence and development of cervical squamous cell carcinoma may be related to the high expression of TGF-β1.