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恶性胶质瘤是发病率高、恶性度高的神经上皮起源肿瘤,WHO分级为III-IV级。目前标准的治疗方法为最大安全切缘的手术切除、放疗加化疗。但恶性胶质瘤浸润性生长的特点使得完全切除非常困难,几乎所有患者都会在原发肿瘤2到3厘米范围内复发。放射治疗可提高恶性胶质瘤的局部控制率,但在部分患者可引起放射性脑损伤,包括:假性进展(pseudoprogression,PP)和放射性脑坏死(radiation necrosis,RN)。
Malignant glioma is a high incidence of malignant tumors of the neural epithelium, WHO grade III-IV level. The current standard of treatment for the maximum margin of safety surgical resection, radiotherapy and chemotherapy. However, the aggressive growth of malignant gliomas makes complete resection difficult and almost all patients will relapse within 2-3 cm of the primary tumor. Radiation therapy can improve the local control rate of malignant glioma, but in some patients can cause radiation brain injury, including: pseudoprogression (PP) and radiation necrosis (radiation necrosis, RN).