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目的探讨近六年本院新生儿败血症血培养主要病原菌及药敏特点。方法选择2006—2011年我院新生儿科收治、血培养阳性的新生儿败血症病例,对致病菌及药物敏感试验进行回顾性分析。结果本组新生儿败血症占同期住院新生儿的2.3%(574/25282)。血培养检出病原菌26种,共574株,其中表皮葡萄球菌288株(50.2%),居首位,其他依次为大肠埃希菌81株(14.1%),溶血葡萄球菌54株(9.4%),肺炎克雷伯菌27株(4.7%)。耐药菌133株,占检出病原菌的23.2%。结论葡萄球菌和大肠埃希菌是新生儿败血症的主要病原菌,在使用抗生素前应进行病原学检查,按药敏结果合理应用抗生素。
Objective To investigate the main pathogenic bacteria and drug susceptibility of neonatal septicemia in blood culture in recent six years. Methods From 2006 to 2011, neonatal septicemia was detected in neonatology and blood cultures in our hospital. The pathogenic bacteria and drug susceptibility tests were retrospectively analyzed. Results This group of neonatal sepsis accounted for 2.3% of hospitalized newborns in the same period (574/25282). A total of 26 pathogenic bacteria were detected in blood culture, of which 574 were Staphylococcus epidermidis (Staphylococcus epidermidis 288, 50.2%), followed by 81 strains (14.1%) of Escherichia coli and Staphylococcus aureus 54 (9.4% , 27 Klebsiella pneumoniae (4.7%). Drug-resistant bacteria 133 strains, accounting for 23.2% of pathogens detected. Conclusion Staphylococcus aureus and Escherichia coli are the main pathogenic bacteria of neonatal sepsis. Before using antibiotics, pathogenic tests should be conducted and antibiotics should be applied reasonably according to the drug susceptibility results.