Activation of the Akt/mTOR signaling pathway: a potential response to long-term neuronal loss in the

• 作 者: Jia-nan Guo Lin-yu Tian Wen-yu Liu Jie Mu Dong Zhou
• 机 构: Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
• 出 处: 中国神经再生研究（英文版）
• 发表日期: 2017年11期
• 关键词: nerve regeneration sepsis cognitive impairment Akt mTOR p70S6K hippocampus neuro

Survivors of sepsis may suffer chronic cognitive impairment as a long-term sequela.However,the precise mechanisms of cognitive dysfunction after sepsis are not well understood.We employed the cecal ligation-and-puncture-induced septic mouse model.We observed elevated phosphorylation of Akt,mammalian target of rapamycin (mTOR) and p70S6K on days 14 and 60,progressive neuronal loss in the cu ammonis 1 region,and abnormal neuronal morphology in the hippocampus in the sepsis mouse model.These findings indicate that changes in neuronal morphology and number in the hippocampus after sepsis were associated with strong activation of the Akt/mTOR signaling pathway,and may reflect a self-rescuing feedback response to neuronal loss after sepsis.