,Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tu

• 作 者: JIANG Yuan TIAN Xuehong YUAN Jie JIN Yuemei TAN Yusong
• 机 构: Department of Obstetrics and Gynecology,Second Hospital,Jilin University,Changchun 130041,China
• 出 处: 中国高等学校学术文摘·医学
• 发表日期: 2007年4期
• 关键词: uterus leiomyosarcoma leiomyoma adrenomedullin angiogenesis prognosis

The aim of this paper was to investigate the relationship between the expression of adrenomedullin(ADM)and microvessel density(MVD)and prognosis in smooth muscle tumor of uterus.The expression of ADM was detected using immunohistochemical staining in specimens from 15 normal controls,28 eases of uterine leiomyoma(LE)and 19 eases of uterine leiomyosarcoma(LES).The MVD was assayed by immunostainting with CD34.There was a positive correlation between the ADM expression and MVD in LE and LES respectively(rs=0.823,P＜0.01;rs=0.793,P＜0.01).The expression of ADM in LE was statistically lower than that in LES(P＜0.05).There was a positive correlation between the ADM expression and mitotic figures in LES(P＜0.05):the more mitotic figures,the higher levels of the ADM expression and poor prognosis.The ADM is an important angiogenic factor in smooth muscle tumor of uterus.The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the prognosis of LES,and as a novel molecular target of anti-angiogenic and anticarcinogenic strategies.