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改善口感和掩盖苦味是口服液体制剂的一个重要研究课题。离子交换树脂是一类能进行离子交换的功能性高分子聚合物,与药物结合形成药物树脂复合物之后,可以改善或屏蔽药物的苦味。国内外已上市的多种产品使用了离子交换树脂作为药用矫味剂。文中简要介绍了离子交换树脂的种类、基本性质、作用原理以及在口服液体制剂矫味中的作用机制、独特优势和应用研究进展。
Improving mouthfeel and masking bitterness are important research topics for oral liquid preparations. Ion exchange resin is a class of ion-exchangeable functional polymer, combined with the drug to form a drug-resin composite, can improve or mask the bitterness of the drug. A variety of products listed at home and abroad have used ion exchange resin as a pharmaceutical flavoring agent. In this paper, the types, basic properties and mechanism of ion exchange resin, the mechanism of action in the flavoring of oral liquid preparations, the unique advantages and application progress are briefly introduced.