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Objective: We investigated the expression levels of KISS-1 and KAI-1 in gallbladder carcinoma and their rela-tionship with clinicopathologic parameters and metastasis potential. Methods: Pathological specimens from 59 gallbladder carcinoma tissues (including 23 invasion tissues), matched 7 para-tumor and 6 normal gallbladder tissues were examined for the expression of KISS-1 and KAI-1 protein by tissue microarray technique and immunohistochemistry (EnVision). Results: The positive rate of KISS-1 and KAI-1 was down-regulated (P < 0.05) in tumor tissues, compared with non-tumor tissues. The positive rate of KISS-1 and KAI-1 were down-regulated (P < 0.01) in invasion tissues, compared with para-tumor tissues. Down-regulating expression levels of KISS-1 and KAI-1 were significantly correlated with some malignant behavior of gall-bladder carcinoma. The positive rate of KISS-1 and KAI-1 were all negatively correlated with the Nevin staging of gallbladder carcinoma (P < 0.01). Moreover, a strong positive correlation was found between the positive expression of KISS-1 and KAI-1 in gallbladder carcinoma (P < 0.001). It was indicated that KISS-1 and KAI-1 were all associated with high metastasis potential of gallbladder carcinoma. Conclusion: KISS-1 and/or KAI-1 may be important markers of reflecting invasive and metastatic potential and prognosis in gallbladder carcinoma, and may be the target genes to inhibit metastasis of gallbladder carcinoma. Detection of the expression of KISS-1 and/or KAI-1 may have important clinical value for finding eady-stage and evaluating the prognosis of gallbladder carcinoma.