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目的检测2型糖尿病患者血糖及血流变学相关指标,分析血糖水平与血流变学相关指标异常之间的关系。方法检测2型糖尿病组(试验组)及健康人群组(对照组)各65例。根据非牛顿流体力学,对系统中流速随时间变化的测量求得不同切变率标本的表观粘度;葡萄糖氧化酶法检测血糖水平;凝集点探测法检测纤维蛋白原水平。结果试验组的全血(高、中、低切)粘度、血糖浓度等指标明显高于对照组(P<0.01);血浆粘度、纤维蛋白原等指标与对照组比较也有显著性差异(P<0.05);红细胞压积与对照组无显著性差异(P>0.05)。2型糖尿病患者血液粘滞性增高,血液流动性降低。血流变学指标和2型糖尿病患者血糖水平密切相关。结论血流变学指标与糖尿病及其并发症的发生发展有相关关系,定期进行血液流变学相关指标检测,可作为2型糖尿病辅助诊断及治疗监测的一项指标。
Objective To detect blood glucose and blood rheology in patients with type 2 diabetes mellitus and to analyze the relationship between blood glucose level and abnormalities of hemorheology-related indicators. Methods Sixty-five patients with type 2 diabetes mellitus (test group) and healthy people (control group) According to non-Newtonian fluid mechanics, the apparent viscosity of samples with different shear rates was obtained by measuring the change of flow velocity in the system with time. The glucose oxidase method was used to detect the blood glucose level. The agglutination point method was used to detect the fibrinogen level. Results The indexes of whole blood (high, medium and low cut) viscosity and blood glucose concentration of the experimental group were significantly higher than those of the control group (P <0.01). The indexes of plasma viscosity and fibrinogen were also significantly different from those of the control group (P < 0.05); hematocrit had no significant difference with the control group (P> 0.05). Patients with type 2 diabetes have increased blood viscosity and reduced blood fluidity. Hemorrheological indicators and type 2 diabetes are closely related to blood glucose levels. Conclusion Hemorrheological indexes are closely related to the occurrence and development of diabetes mellitus and its complications. Regular detection of hemorheological indexes can be used as an indicator for the diagnosis and treatment of type 2 diabetes mellitus.