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目的:探讨超敏C反应蛋白(high sensitivity-C reactive protein,Hs-CRP)水平在外周T细胞淋巴瘤(peripheral T-cell lymphoma,PTCL)患者预后中的意义。方法:回顾性分析2005年1月1日至2016年12月31日浙江大学医学院附属第一医院就诊的初治PTCL患者247例,其中在随访过程中失访13例,实际入组234例,患者中位年龄48岁;治疗前检测Hs-CRP水平,同时完善相关检查以明确肿瘤分期及国际预后指数(international prognostic index,IPI),中位随访时间23个月,观察Hs-CRP水平与患者总生存期(overall survival,OS)的关系。结果:Hs-CRP水平与IPI评分(r=0.132,P<0.01)、Ann Arbor分期(r=0.183,P=0.005)、B症状(r=0.225,P=0.001)、乳酸脱氢酶(lactate dehydrogenase,LDH)(r=0.169,P=0.009)呈正相关(P<0.05);与血浆白蛋白水平(r=-0.343,P<0.001)、血红蛋白浓度(r=-0.239,P<0.001)、血小板计数(r=0.131,P=0.045)呈负相关(P<0.05);与年龄、性别、体能(ECOG)评分、白细胞计数无显著相关性(P>0.05),血清Hs-CRP≤10 mg/L较Hs-CRP>10 mg/L患者具有更好的OS(P<0.05)。单因素分析及多因素Cox回归模型显示血小板计数、Hs-CRP、白蛋白水平、IPI评分是OS的独立预后不良因素(P<0.05)。结论:PTCL患者治疗前血清Hs-CRP水平可以和IPI评分一样作为PTCL预后的指标。
Objective: To investigate the significance of high sensitivity-C reactive protein (Hs-CRP) in the prognosis of patients with peripheral T-cell lymphoma (PTCL). Methods: A retrospective analysis of January 1, 2005 to December 31, 2016 in Zhejiang University School of Medicine, First Affiliated Hospital of PTCT patients treated 247 cases, of which 13 were lost to follow-up visit, the actual 234 patients admitted to the group , The median age of patients was 48 years old. The level of Hs-CRP was detected before treatment. At the same time, the related examination was performed to clarify the tumor staging and international prognostic index (IPI). The median follow-up time was 23 months. Patient’s overall survival (overall survival, OS) relationship. Results: The correlation between Hs-CRP level and IPI score (r = 0.132, P <0.01), Ann Arbor stage (r = 0.183, P = 0.005), B symptom (r = 0.225, P = 0.001), lactate dehydrogenase (r = -0.343, P <0.001), hemoglobin concentration (r = -0.239, P <0.001), plasma albumin level (r = -0.239, P = 0.009) (P <0.05), but no significant correlation with age, gender, ECOG score and white blood cell count (P> 0.05), serum Hs-CRP≤10 mg / L had better OS (P <0.05) than Hs-CRP> 10 mg / L. Univariate analysis and multivariate Cox regression model showed that platelet count, Hs-CRP, albumin level and IPI score were the independent prognostic factors of OS (P <0.05). Conclusions: Serum Hs-CRP level in PTCL patients can be used as an index of prognosis of PTCL just like IPI score.