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肝细胞生长因子(hepatocyte growth factor,HGF)是1984年日本学者Nakamura等从部分肝切除大鼠血浆中分离纯化获得一种能刺激原代培养肝细胞生长、促进肝细胞DNA合成的肝源性活性因子,Nakamura又于1989年成功地克隆了大鼠和人的肝细胞生长因子(HGF)的cDNA并进行了表达。最初认为
Hepatocyte growth factor (HGF) was isolated and purified from the plasma of partial hepatectomy rats by Japanese scholar Nakamura et al. In 1984 to obtain a kind of liver-derived activity that can stimulate the growth of primary cultured hepatocytes and the DNA synthesis of hepatocytes Factor, Nakamura successfully cloned and expressed rat and human hepatocyte growth factor (HGF) cDNA in 1989. At first thought