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胃肠道间质瘤(GIST)是最常见的胃肠道间叶源性肿瘤,约占胃肠道间叶肿瘤的70％,主要发生在40～70岁的中老年患者.其在内镜下的表现一般为黏膜下隆起,与胃肠道平滑肌瘤、神经鞘瘤、异位胰腺等难鉴别,因而确诊主要依靠病理组织学检查及免疫组织化学染色.随着治疗方案的不断改进,胃肠道间质瘤可通过传统开腹手术、腹腔镜手术、内镜下手术、腹腔镜联合内镜手术、靶向治疗、免疫治疗等方式治疗,文章对近年来有关GIST的诊治进展进行综述.“,”The gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract,accounting for about 70％ of all gastrointestinal mesenchymal tumors.GIST occurs mainly in middle-aged and elderly patients aged between 40 and 70.Its performance under endoscopy is submucous eminence,which is difficult to identify with gastrointestinal leiomyoma,neurilemmoma,ectopic pancreas and so on.Therefore,the diagnosis of GIST depends mainly on histopathological examination and immunohistochemical staining.With the continuous improvement of follow-up treatment programmes,GIST can be treated by traditional laparotomy,laparoscopic surgery,endoscopic surgery,laparoscopy combined with endoscopic surgery,targeted therapy and immuno therapy.