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至2000年11月,瑞典不良反应数据库已有311例抗痛风药别嘌醇(allopurinol)的报告,详述了423例不良反应。常见的为皮肤反应(220例)、血液系统异常(69例)、全身症状和体征(40例)、肝胆系统紊乱(35例)和胃肠道反应(19例)。 血液系统异常中有6例是致命的再生障碍性贫血,别嘌醇剂量为每天100～300mg;其中女性4例,男性2例,年龄>70岁5例,55岁1例。在出现再生障碍性贫血症状时,4名患者已服用别嘌醇35个月,其余2名已用药数年,并已住院数周
As of November 2000, there have been 311 reports of allopurinol, an anti-gout drug, and 423 adverse reactions were described in the Swedish ADR database. Common skin reactions (220 cases), abnormal blood system (69 cases), systemic symptoms and signs (40 cases), hepatobiliary disorders (35 cases) and gastrointestinal reactions (19 cases). Six of the hematologic abnormalities were fatal aplastic anemia. Allopurinol doses ranged from 100 to 300 mg per day. There were 4 females, 2 males, 5 females> 70 years old and 1 case 55 years old. In the presence of aplastic anemia symptoms, 4 patients have been taking allopurinol 35 months, the remaining two have been used for several years and have been hospitalized for several weeks