Evaluation and Prediction of Joint Toxicity of Aniline and Its Derivatives to Photobacterium Phospho

• 作 者: YUAN Xing SU Li-min SONG Li-li
• 机 构: Department of Environmental Science
• 出 处: 高等学校化学研究（英文版）
• 发表日期: 2004年期
• 关键词: QSAR Photobacterium phosphoreum Joint toxicity Simple addition

The single toxicity of aniline and its derivatives and the joint toxicity of the binary mixtures of aniline and each of its derivatives with the toxic unit ratios of 1∶1, 1∶4, 4∶1 to photobacterium phosphoreum were determined, respectively. The toxic unit and the additive index were used to evaluate the joint toxicity. The result shows that the joint toxicity of each of the binary mixtures of aniline and each of its derivatives is mainly simple addition of the toxicities of the two compounds. On this basis, the QSAR equation that was built from the single toxicity of aniline was used to predict the toxicity of the derivatives of aniline in the mixtures. Good agreement between the predicted and experimental values was found with R2=0.921.