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目的评价探讨液基薄层细胞学(Thin-Prep-liquid-based cytology test,TCT)及HPV联合检测筛查宫颈病变的准确性。方法对310例TCT检查标本采用TBS(the bethesda system)诊断系统进行诊断,并对所有病人进行阴道镜下宫颈活检,分析TCT检查结果与病理活检的符合率。结果 TCT阳性者233例,敏感度为75.16%,HPV DNA检测阳性270例,敏感度87.09%,与TCT检测的敏感度相比有极显著差异(P<0.05))。结论对于宫颈癌及其癌前病变的筛查及早期诊断,应以宫颈细胞学检查和高危HPV检测相互结合以提高检出率,降低假阴性
Objective To evaluate the accuracy of thin-prep-liquid-based cytology (TCT) and HPV detection in screening cervical lesions. Methods A total of 310 cases of TCT were diagnosed by using the system of TBS (the bethesda system). All the patients underwent colposcopic biopsy and colposcopy. The coincidence rates of TCT and biopsy were analyzed. Results There were 233 cases with positive TCT, the sensitivity was 75.16%. The HPV DNA test was positive in 270 cases with the sensitivity of 87.09%. There was a significant difference (P <0.05) compared with the sensitivity of TCT test. Conclusion For the screening and early diagnosis of cervical cancer and precancerous lesions, cervical cytology and high-risk HPV testing should be combined to improve the detection rate and reduce the false-negative