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目的通过对52例妊娠期肝内胆汁淤积症孕妇的临床分析,探讨减低胎死宫内,新生儿窒息或死亡的预防措施。方法收集我院2000年1月-2008年1月在我院分娩的ICP孕妇52例为ICP组,设观察同期分娩的52例正常孕妇为对照,比较两组间的胎儿窘迫、羊水粪染、新生儿窒息、新生儿肺炎、早产的发生率。结果ICP组胎儿窘迫、羊水粪染、新生儿窒息、早产的发生率分别为36.73%、24.49%、8.16%、28.57%,与对照组比较差异有统计学意义(P<0.05),新生儿肺炎差异无显著性。结论ICP可导致胎儿窘迫、羊水粪染、新生儿窒息、早产。
Objective To analyze the clinical analysis of 52 pregnant women with intrahepatic cholestasis of pregnancy, and to explore the preventive measures to reduce neonatal asphyxia or death of fetal death. Methods 52 cases of ICP pregnant women who were delivered in our hospital from January 2000 to January 2008 were enrolled as ICP group. Fifty-two normal pregnant women who delivered at the same period were selected as control group. Fetal distress, meconium-stained amniotic fluid, Neonatal asphyxia, neonatal pneumonia, the incidence of preterm birth. Results The incidences of fetal distress, meconium-stained amniotic fluid, neonatal asphyxia and preterm labor in ICP group were 36.73%, 24.49%, 8.16% and 28.57%, respectively, which were significantly different from those in control group (P <0.05) No significant difference. Conclusion ICP can cause fetal distress, meconium-stained amniotic fluid, neonatal asphyxia and premature delivery.