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目的:观察间歇性低氧对大鼠脑线粒体功能的影响。方法:成年雄性Wister大鼠随机分为对照组和间歇性低氧组(海拔5 000m,4h·d-1,共7d),分离提取脑线粒体,检测线粒体呼吸功能、腺苷酸含量以及线粒体膜电位和通透性。结果:两组脑线粒体呼吸功能无显著差别。间歇性低氧组线粒体AMP含
Objective: To observe the effect of intermittent hypoxia on mitochondrial function in rat brain. Methods: Adult male Wistar rats were randomly divided into control group and intermittent hypoxia group (5 000 m altitude, 4 h · d-1 for 7 days). Mitochondria were isolated and extracted for detecting mitochondrial respiratory function, adenosine content and mitochondrial membrane Potential and permeability. Results: There was no significant difference in mitochondrial respiratory function between the two groups. Intermittent hypoxia group mitochondrial AMP containing