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目的:观察奥美拉唑+阿莫西林+甲硝唑三联疗法与雷尼替丁+阿莫西林+甲硝唑三联疗法治疗十二指肠球部溃疡(DU)患者的疗效。方法:将86例幽门螺杆菌(HP)感染的活动性DU患者随机分成治疗组(60例)和对照组(26例)。治疗组:奥美拉唑1组32例,采用奥美拉唑20mg每日2次+阿莫西林0.5g每日3次+甲硝唑0.4g每日3次口服1周奥美拉唑2组28例,采用奥美拉唑20m每日2次+阿莫西林0.5g每日3次+甲硝唑0.4g每日3次口服4周。对照组雷尼替丁150mg每日2次+阿莫西林05g每日3次+甲硝唑0.4g每日3次口服4周。结果:奥美拉唑1组、2组及雷尼替丁组溃疡愈合率分别为90.65%、9285%、76.92%。6个月后溃疡复发率分别为6.89%、3.84%、20%。奥美拉唑1组与2组比较无明显差异,奥美拉唑组与雷尼替丁组比较有显著差异,P<0.05。奥美拉唑组与雷尼替丁组HP根除率分别为93.75%、96.43%、73.07%,P<0.05。结论:奥美拉唑+阿莫西林+甲硝唑三联疗法治疗DU愈合率高,HP根除率高,优于雷尼替丁组。
Objective: To observe the efficacy of omeprazole + amoxicillin + metronidazole triple therapy combined with ranitidine + amoxicillin + metronidazole triple therapy in patients with duodenal ulcer (DU). Methods: Eighty-six active DU patients with Helicobacter pylori (HP) infection were randomly divided into treatment group (60 cases) and control group (26 cases). Treatment group: Omeprazole group 1 32 cases, with omeprazole 20mg twice daily + amoxicillin 0.5g 3 times daily + metronidazole 0.4g orally 3 times a day omeprazole 2 Group 28 cases, using omeprazole 20m 2 times a day + amoxicillin 0.5g 3 times a day + metronidazole 0.4g 3 times a day orally for 4 weeks. The control group ranitidine 150mg twice daily + amoxicillin 05g 3 times a day + metronidazole 0.4g 3 times a day orally for 4 weeks. Results: The ulcer healing rates of omeprazole group 1, group 2 and ranitidine group were 90.65%, 9285% and 76.92%, respectively. 6 months after ulcer recurrence rates were 6.89%, 3.84%, 20%. There was no significant difference between omeprazole group 1 and 2 group, there was significant difference between omeprazole group and ranitidine group (P <0.05). The eradication rates of HP in omeprazole group and ranitidine group were 93.75%, 96.43% and 73.07%, respectively, P <0.05. Conclusion: The omeprazole + amoxicillin + metronidazole triple therapy in the treatment of DU high healing rate, HP eradication rate, superior to the ranitidine group.