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Mutations of integrin-interacting protein Kindlin-1 cause Kindler Syndrome and deregulation of Kindlin-1 is implicated in human cancers. The Kindlin-1-related diseases are confined in limited tissue types. However , Kindlin-1 tissue distribution and the dogma that govs Kindlin-1 expression in normal human body are elusive. This study examined Kindlin-1 expression in normal human adult organs, human and mouse embryonic or-gans by immunohistochemical analyses. We identified a general principle that the level of Kindlin-1 expression in tissues is tightly correlated with the corresponding germ layers from which these tissues are originated. We com-pared the expression of Kindlin-1 with Kindlin-2 and found that Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm, whereas Kindlin-2 is mainly expressed in mesoderm-derived tissues. Like-wise, Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in human and mouse em-bryos. Our findings indicate that Kindlin-1 may play an importance role in the development of endoderm/ectoderm related tissues.