论文部分内容阅读
恶性肿瘤易发生骨转移,临床极为常见。既往靠 X 线诊断,但骨转移癌的早期诊断尚有困难,近年来由于核医学仪器及核素治疗药物的研制取得重要进展。目前 SPECT 全身骨显像已成为诊断早期骨转移癌的最主要的检查方法,核素靶治疗亦为临床开辟了新的治疗途径。1 骨转移癌的核医学诊断1.1 全身骨显像显像原理:骨显像剂~(99m)Tc—MDP(亚甲基二膦酸盐)能被骨的无机盐—羟基磷灰石晶体表面吸附,进行离子交换,并能与骨有饥质—未成熟的骨胶原结合而使骨显影,应用
Malignant tumors are prone to bone metastases, and clinical practice is extremely common. Although X-ray diagnosis was previously used, early diagnosis of bone metastases is still difficult. In recent years, important advances have been made in the development of nuclear medicine instruments and radionuclide therapeutics. At present, SPECT whole body bone imaging has become the most important examination method for diagnosing early bone metastases, and radionuclide target therapy has also opened up new therapeutic approaches for clinicians. 1 Nuclear medicine diagnosis of bone metastatic carcinoma 1.1 Principle of whole body bone imaging imaging: bone imaging agent ~ (99m) Tc-MDP (methylene diphosphonate) can be bone inorganic salt - hydroxyapatite crystal surface Adsorption, ion exchange, and bone development by combining with hunger-immature bone collagen