孕激素及其受体与骨代谢

• 作 者: 刘石平
• 机 构: 湖南医科大学附属第二医院代谢内分泌所 410011
• 出 处: 国外医学(老年医学分册)
• 发表日期: 2000年04期
• 关键词: 孕激素 糖皮质激素受体 破骨细胞 降钙素 雌激素 动物实验 骨吸收 骨小结 骨代谢 骨细胞

绝经是雌、孕激素同时缺乏的状态,雌激素与骨代谢的关系已确定,近年来的研究显示孕激素与骨代谢也有密切关系。成骨细胞和破骨细胞上孕激素受体的发现为孕激素调节骨细胞提供了直接证据。目前已证实,孕激素影响成骨细胞的增殖和分化,竞争糖皮质激素受体,影响骨吸收。孕激素还可能通过影响钙调节激素如甲状旁腺激素和降钙素的分泌参与骨代谢。动物实验和临床资料显示孕激素对骨代谢有益。

Menopause is a state of estrogen and progesterone deficiency at the same time. The relationship between estrogen and bone metabolism has been established. In recent years, studies have shown that progesterone is also closely related to bone metabolism. The discovery of progesterone receptors on osteoblasts and osteoclasts provides direct evidence that progestins regulate osteocytes. It has been confirmed that progesterone affects the proliferation and differentiation of osteoblasts, competes for glucocorticoid receptors and affects bone resorption. Progesterone may also be involved in bone metabolism by affecting the secretion of calcium-regulating hormones such as parathyroid hormone and calcitonin. Animal experiments and clinical data show that progesterone is beneficial to bone metabolism.