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本文综述使用各种类脂后,亲油性、亲水性或大分子药物等肠道吸收的改变。类脂对药物吸收的影响因加入类脂的结构和物理状态而异。本文讨论了含乳剂、脂质体和胶束状态的类脂对药物穿过肠道的吸收机制。使用胶束状态的致融类脂(fusogenic lipid)能极有效地使一些难吸收的药物(如抗生素类和大分子化合物)进行吸收。而且,在胃肠道内,其促进吸收的能力以结肠直肠区为最大。致融类脂对带有大分子载体的药物的选择性
This article reviews the changes in intestinal absorption such as lipophilicity, hydrophilicity, or macromolecular drugs after the use of various lipids. The effect of lipids on drug absorption varies according to the structure and physical state of the lipid added. This article discusses the absorption mechanism of drugs across the intestine by lipids containing emulsions, liposomes and micelles. The use of fusogenic lipids in the micellar state can effectively absorb some of the less-resorbable drugs such as antibiotics and macromolecular compounds. Moreover, its ability to promote absorption in the gastrointestinal tract is maximized in the colorectal region. Selective lipids on macrophages-loaded drugs