Solid Phase Synthesis of 2-Substituted 1,3-Oxazin-6-ones Using Resin-bound Cyclic Malonic Acid Ester

• 作 者: 刘占祥 阮秀秀 黄宪
• 机 构: Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China ,Depart
• 出 处: Chinese Journal of Chemistry
• 发表日期: 2004年02期
• 关键词: heterocyclic resin equiv carbonyl afford facile substituted aromatic ketone clea

A facile solid phase synthesis of 2-substituted 1,3-oxazin-6-ones using polymer-supported Meldrums acid has been reported. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent dou-ble substitution with amide, afforded the corresponding polymer-supported acylaminomethylene cyclic malonic acid ester, which upon thermal treatment led to 1, 3-oxazin-6-ones in good yields and with high purity.

A facile solid phase synthesis of 2-substituted 1,3-oxazin-6-ones using polymer-supported Meldrums acid has been reported. Reaction of the resin-bound cyclic malonic acid ester with triethyl orthoformate and subsequent dou-ble substitution with amide, afforded the corresponding polymer-supported acylaminomethylene cyclic malonic acid ester, which upon thermal treatment led to 1, 3-oxazin-6-ones in good yields and with high purity.