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目的观察辨证论治与针灸联合EXO化疗方案用于晚期胃癌对患者的血清学因子水平的影响。方法将192例晚期胃癌患者随机分为研究组和对照组各96例。对照组只给予EXO化疗方案,研究组在对照组基础上联合应用辨证论治与针灸治疗。比较2组患者治疗前后干拢素-γ(IFN-γ)、肿瘤坏死因子-α(TNF-α)、白细胞介素-4(IL-4)及白细胞介素-10(IL-10)水平的变化。结果治疗前2组IFN-γ、TNF-α、IL-4和IL-10水平差异无统计学意义(P>0.05)。治疗后,2组患者的IFN-γ、TNF-α水平均升高,IL-4及IL-10水平均降低,且研究组波动幅度大于对照组,差异均具有统计学意义(P<0.05)。结论辨证论治与针灸联合EXO化疗方案治疗晚期胃癌,可显著改善患者IFN-γ、TNF-α、IL-4及IL-10等炎性因子水平,能改善患者的病情,效果显著,值得推广应用。
Objective To observe the effect of syndrome differentiation and syndrome differentiation combined with acupuncture and moxibustion combined with EXO chemotherapy regimen on serum serological factors in patients with advanced gastric cancer. Methods 192 patients with advanced gastric cancer were randomly divided into study group and control group, 96 cases each. The control group only given EXO chemotherapy, the study group in the control group based on the combination of syndrome differentiation and acupuncture treatment. The levels of IFN-γ, TNF-α, IL-4 and IL-10 in the two groups were compared before and after treatment The change. Results There was no significant difference in the levels of IFN-γ, TNF-α, IL-4 and IL-10 between the two groups before treatment (P> 0.05). After treatment, the levels of IFN-γ and TNF-α in both groups increased, the levels of IL-4 and IL-10 decreased, and the fluctuation range of the study group was larger than that of the control group (P <0.05) . Conclusion Syndrome Differentiation and Acupuncture Combined with EXO Chemotherapy Regimen for Advanced Gastric Cancer can significantly improve the levels of inflammatory cytokines such as IFN-γ, TNF-α, IL-4 and IL-10 in patients with advanced gastric cancer, and can improve the patient’s condition.