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目的分析2型糖尿病(T2DM)合并代谢综合症(METS)患者血清尿酸(UA)水平与血液流变学指标的相关性。方法选取自2012年1月到2016年4月于广西壮族自治区职业病防治研究院收治的T2DM患者98例,按照有无合并METS分为单纯T2DM组(TD组)48人、T2DM合并METS组(TS组)50人,同时选取50名健康人员作为对照组。观察三组患者体重指数(BMI)、血糖、血脂、UA以及血液流变学相关指标检测情况。结果 TD组、TS组患者BMI、血糖、血脂、UA水平相比于对照组,差异均有统计学意义(P<0.05);TD组和TS组患者血液流变学指标均高于对照组,差异有统计学意义(P<0.05);TD组与TS组患者各指标相比,差异有统计学意义(P<0.05)。UA与BMI、血糖、血脂以及血液流变学指标具有显著的相关性,当前者一定时,UA水平与血浆黏度、血细胞比容、红细胞聚集指数等血液流变学指标呈正相关。结论 T2DM合并METS患者UA水平与血液流变学指标呈正相关,应降低UA水平。
Objective To analyze the relationship between serum uric acid (UA) and hemorheology in patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome (METS). Methods From January 2012 to April 2016, 98 patients with T2DM were enrolled in the Occupational Disease Prevention and Treatment Institute of Guangxi Zhuang Autonomous Region. According to the presence or absence of METS, 48 patients were divided into T2DM group (TD group), T2DM combined with METS group TS group) 50 people, while selecting 50 healthy people as the control group. Body mass index (BMI), blood glucose, blood lipid, UA and hemorheology related indexes were observed in the three groups. Results Compared with the control group, the differences of BMI, blood glucose, blood lipids and UA in TD group and TS group were statistically significant (P <0.05). The indexes of hemorheology in TD group and TS group were higher than those in control group, The difference was statistically significant (P <0.05); TD group and TS patients compared to each index, the difference was statistically significant (P <0.05). There was a significant correlation between UA and BMI, blood glucose, blood lipids and hemorheology indexes. When the former is definite, UA level is positively correlated with hemorheological indexes such as plasma viscosity, hematocrit and erythrocyte aggregation index. Conclusion UA levels in patients with T2DM and METS are positively correlated with hemorrheological parameters, and UA level should be decreased.