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Aim: To determine the immunogenicity of routine vaccination against diphtheria , tetanus, and Haemophilus influenzae type b (Hib) in Asian infants born in the UK, and whether maternal antibody suppression occurs. Methods: A cohort study wi th 80%power, within 95%confidence limits, to show that 80%or fewer Asian infa nts would respond with an anti-PRP antibody concentration>0.15 μg/ml. Infants of South Asian origin born in Berkshire were enrolled at two general practices i n Reading: 41 Asian families sequentially asked to participate within 2 weeks of birth; 36 infants were enrolled and 34 completed the study. Main outcome measur es were: antibody concentration against diphtheria, tetanus, and Hib expressed a s geometric mean titres (GMT) and proportion of infants about a threshold protec tive antibody concentration. Results: Median age for completing primary vaccinat ion course was 5 months. All 34 achieved anti-PRP antibody concentration of >0. 15 μg/ml, 33 were >1.0 μg/ml, and the GMT was 15.0 μg/ml. All infants develop ed protective antibody concentration >0.1 IU/ml for tetanus and diphtheria; the respective GMTs were 1.94 and 5.57 IU/ml. Infants with high (>0.25 IU/ml) antibo dy concentrations against diphtheria and tetanus at 2 months achieved lower anti body concentrations after their three dose course than those with low concentrat ions (< 0.1 IU/ml) (p = 0.06 and 0.03, respectively). Conclusions: Despite evide nce for maternal antibody suppression of the response to tetanus and diphtheria vaccination, excellent antibody responses were achieved by routine vaccination a ccording to the accelerated schedule. High vaccine coverage should be encouraged to provide protection against the possibility of imported infection.
Aim: To determine the immunogenicity of routine vaccination against diphtheria, tetanus, and Haemophilus influenzae type b (Hib) in Asian infants born in the UK, and whether maternal antibody suppression occurs. Methods: A cohort study wi th 80% power, within 95 % confidence limits, to show that 80% or less Asian infants would respond with an anti-PRP antibody concentration> 0.15 μg / ml. Infants of South Asian origin born in Berkshire were enrolled at two general practices in Reading: 41 asked to participate within 2 weeks of birth; 36 infants were enrolled and 34 completed the study. Main outcome measur es were: antibody concentration against diphtheria, tetanus, and Hib expressed as geometric mean titres (GMT) and proportion of infants about a threshold protec Results: Median age for completing primary vaccinat ion course was 5 months. All 34 achieved anti-PRP antibody concentration> 0.15 μg / ml, 33 were> 1.0 μg / ml, and th Infants with high (> 0.25 IU / ml) antibo dy concentrations against (0.1 IU / ml for tetanus and diphtheria) diphtheria and tetanus at 2 months achieved lower anti body concentrations after their three dose course than those with low concentrat ions (<0.1 IU / ml) (p = 0.06 and 0.03, respectively). Conclusions: Despite evide nce for maternal antibody suppression of the response to tetanus and diphtheria vaccination, excellent antibody responses were achieved by routine vaccination a ccording to the accelerated schedule. High vaccine coverage should be encouraged to provide protection against the possibility of imported infection.