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目的 探讨前列腺间质肉瘤的临床病理特征。方法对两例该肿瘤作常规ＨＥ染色及免疫组织化学标记，在光镜下观察组织学形态及免疫组化表达。结果前列腺间质肉瘤是发生于前列腺特异性间质细胞的肿瘤。发病高峰在老年人（５０～６９岁）。镜下肿瘤组织以间质细胞高度增生伴中－高度异型为特征。病变内可含良性前列腺腺体成分，类似于乳腺的叶状囊肉瘤。免疫组化表达Ｖｉｍｅｎｔｉｎ，ＣＤ３４及ＰＲ阳性。结论 前列腺间质肉瘤是一种在组织学特征及免疫组化表型上都不同于其他间叶性肿瘤的激素依赖性肿瘤。激素治疗有效。应将其作为一种独立的肿瘤诊断。
Objective To investigate the clinicopathological features of prostate stromal sarcoma. Methods Two cases of this tumor were subjected to routine HE staining and immunohistochemical staining. Histological examination and immunohistochemistry were observed under light microscope. Results Prostate stromal sarcoma was a tumor of prostate-specific stromal cells. The peak incidence in the elderly (50 to 69 years old). Microscopic tumor tissue is characterized by a high degree of interstitial hyperplasia with moderate-high atypia. Lesions may contain benign prostatic gland composition, similar to the breast phyllodes cyst. Immunohistochemical expression of Vimentin, CD34 and PR positive. Conclusions Prostate stromal sarcoma is a hormone-dependent tumor that differs from other mesenchymal tumors both histologically and immunohistochemically. Hormone therapy is effective. It should be diagnosed as an independent tumor.