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目的探讨肺癌患者血清铁蛋白的表达及临床意义。方法收集并检测174例肺癌患者和85例肺良性病变患者术前血清铁蛋白水平,并分析血清铁蛋白水平与肺癌临床病理特征间的关系。结果肺癌患者血清铁蛋白显著高于肺良性病变患者,鳞癌、肿瘤较大、低分化和晚期的非小细胞肺癌患者血清铁蛋白分别显著高于腺癌、肿瘤较小、高一中分化和早期的患者。结论血清铁蛋白可能在肺癌的发生和进展中起到促进作用。
Objective To investigate the expression of serum ferritin in patients with lung cancer and its clinical significance. Methods Preoperative serum ferritin levels were collected from 174 patients with lung cancer and 85 patients with benign lung disease. The relationship between serum ferritin level and clinicopathological features of lung cancer was analyzed. Results Serum ferritin was significantly higher in patients with lung cancer than in patients with benign lung disease. The serum ferritin in patients with squamous cell carcinomas and tumors with relatively large tumors, poorly differentiated patients and patients with advanced non-small cell lung cancer were significantly higher than those with adenocarcinoma, Early patients. Conclusion Serum ferritin may promote the occurrence and progression of lung cancer.