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目的:评价CTLA-4基因多态性与系统性红斑狼疮(SLE)易感性之间的相关性。方法:检索PubMed、Web of Knowledge、Embase、万方学术期刊全文数据库、中国期刊全文数据库和中国生物医学数据库,检索CTLA-4多态性与SLE易感性相关的文献,末次检索时间为2012-05-20。使用Meta分析方法对数据进行分析。结果:共纳入12篇文献,共涉及CTLA-4启动子区域3个多态位点:-1722、-166及-318位点,全人群研究结果显示在CTLA-4基因-1722T/C多态性(显性模型下:OR=2.570,95%CI=1.845-3.581,P<0.01)及-318T/C多态性(隐性模型:OR=0.044,95%CI=0.020-0.094,P<0.01)与SLE存在统计学上的相关性,人群分层后亚裔人群中-1722T/C及-318T/C多态性与SLE的此种相关性仍存在,但欧裔及非裔人群的CTLA-4启动区所有研究位点均未发现与SLE有关。结论:CTLA-4基因1722T/C及-318T/C多态性可能与SLE人群易感性有关,特别是亚裔人群。
Objective: To evaluate the association between CTLA-4 gene polymorphism and the susceptibility to systemic lupus erythematosus (SLE). Methods: PubMed, Web of Knowledge, Embase, Wanfang Academic Journal Full-text Database, Chinese Journal Full-text Database and China Biomedical Database were searched. The literature about CTLA-4 polymorphism and susceptibility to SLE was searched. The last search time was 2012-05 -20. Meta-analysis methods were used to analyze the data. Results: A total of 12 articles were included in this study, which involved three polymorphic sites of -1722, -166 and -318 in the CTLA-4 promoter region. The results of the whole population study showed that in the CTLA-4 gene -1722T / C polymorphism (OR = 2.570, 95% CI = 1.845-3.581, P <0.01) and -318T / C polymorphisms (recessive model: OR = 0.044, 95% CI = 0.020-0.094, P < 0.01) was correlated with SLE. The correlation between -1722T / C and -318T / C polymorphisms in Asian population and SLE still exists after stratification, but the differences between European and African descent No study sites in the CTLA-4 promoter region were associated with SLE. Conclusion: The 1722T / C and -318T / C polymorphisms of CTLA-4 gene may be related to the susceptibility of SLE population, especially in Asian population.