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探讨了小鼠孕期和哺乳期饲喂轻度缺锌饲料对仔鼠学习记忆能力的影响．实验动物为成年雌性ICR小鼠30只及其所产的仔鼠30只．怀孕母鼠随机分为3组：（A）对照组；（B）孕期及哺乳期轻度缺锌组及（C）孕期轻度缺锌组．对照饲料及轻度缺锌饲料的锌含量分别为100mgZn／kg和5mgZn／kg。A组小鼠饲喂对照饲料；B组小鼠孕期及哺乳期皆饲喂轻度缺锌饲料，而C组孕期饲喂缺锌饲料、哺乳期饲唱对照饲料．断奶后（出生第20天后）仔鼠饲喂对照饲料。70日龄（P70）后分别在穿梭箱内测试备组仔鼠的学习能力。行为测试则采用条件性回避反应模型。实验结果表明，BRC组仔鼠达到学会标准所需次数分别为45．0±5．9（n＝7）和41．7±4．8（n＝12），明显多于A组（34．7±3．9，n＝11），而B组与C组间无显著性差异。行为实验结束后，在A组和B组仔鼠的海马脑片上进行了诱导长时程增强（LTP）的实验，B组脑片上诱导的LTP明显低于A组。结果提示：孕期及哺乳期锌缺乏可造成学习能力的下降，同时也影响海马的突触可塑性，而孕期可能是锌缺乏造成这种脑功能损伤的关键时期．
The effects of mild zinc deficiency diet during pregnancy and lactation on the learning and memory ability of offspring mice were explored. The experimental animals were 30 adult female ICR mice and 30 offspring. Pregnant females were randomly divided into 3 groups: (A) control group; (B) mild zinc deficiency during pregnancy and lactation; and (C) mild zinc deficiency during pregnancy. The zinc content of the control and mild zinc deficient diets was 100 mg Zn / kg and 5 mg Zn / kg, respectively. Group A mice were fed with control diet; Group B mice were fed with mild zinc deficiency during pregnancy and lactation, while group C was fed with zinc deficiency diet during lactation and lactation feed during lactation. After weaning (after day 20 of birth) pups were fed the control diet. 70-day-old (P70) were tested in the shuttle box prepared pupil learning ability. Behavioral tests use a conditional avoidance response model. The experimental results showed that the number of times needed to reach the standard of learning was 45.0 ± 5.9 (n = 7) and 41.7 ± 4.8 (n = 12) in BRC group, significantly higher than that in group A (34. 7 ± 3.9, n = 11), while there was no significant difference between group B and group C. At the end of the behavioral experiment, long-term potentiation (LTP) was induced in hippocampal slices of group A and group B pups, and LTP induced in group B was significantly lower than that of group A. The results suggest that zinc deficiency during pregnancy and lactation can reduce the learning ability and synaptic plasticity of the hippocampus. Pregnancy may be a critical period of brain damage caused by zinc deficiency.