论文部分内容阅读
目的比较纳洛酮分别联合更昔洛韦与病毒唑辅治小儿病毒性脑炎的疗效。方法选取2013年1月-2014年5月在儿科就诊的病毒性脑炎患儿120例,随机分为A组和B组各60例,在常规治疗的基础上,A组给予纳洛酮联合更昔洛韦治疗,B组给予纳洛酮联合病毒唑治疗,疗程均为7~10d。治疗过程中密切观察2组患儿的生命体征、病情变化、临床疗效、症状改善情况及不良反应发生情况。结果 A组的显效率和总有效率均高于B组,发热、头痛、抽搐、意识障碍消失时间均短于B组,不良反应发生率低于B组,差异均有统计学意义(P<0.05)。结论纳洛酮联合更昔洛韦辅治小儿病毒性脑炎的临床疗效优于纳洛酮联合病毒唑,且临床症状、体征消失时间均较短,不良反应少,值得临床推广使用。
Objective To compare the efficacy of naloxone with ganciclovir and ribavirin in the treatment of pediatric viral encephalitis. Methods A total of 120 children with viral encephalitis from January 2013 to May 2014 were selected and randomly divided into group A and group B, 60 cases each. On the basis of routine treatment, group A was given naloxone combined Ganciclovir treatment, B group given naloxone combined with ribavirin treatment, treatment were 7 ~ 10d. During the treatment, the vital signs, the changes of the disease, the clinical curative effect, the improvement of symptoms and the occurrence of adverse reactions in the two groups were observed closely. Results The markedly effective rate and total effective rate of group A were higher than that of group B. The time of fever, headache, convulsion and disappearance of disturbance of consciousness were shorter in group A than in group B, and the incidence of adverse reactions was lower than that in group B (P < 0.05). Conclusion The clinical efficacy of naloxone combined with ganciclovir in the treatment of infantile viral encephalitis is better than that of naloxone and ribavirin. The clinical symptoms and signs disappear shortly with fewer adverse reactions and is worthy of clinical promotion.