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甘露醇是神经外科最常用的药物之一,其对脑组织的渗透性脱水作用是众所周知的.有人推测,甘露醇除了有脱水、降低脑血管阻力和增加脑血流量的作用外,尚有降低血液粘稠度的作用.作者对此作了血液流变学的测定.对11例颅内动脉瘤手术的病人,在手术开始时静脉输入1克/公斤的甘露醇,在输入前和输入后的半小时、2小时和4小时各取肝素化血标本一次,在37℃时依次测定影响血粘稠度的四个主要因素:1.血浆粘稠度,2.红细胞压积,3.红细胞聚集性和4.红细胞变形性.同时用标准方法测定红细胞压积、
Mannitol is one of the most commonly used drugs in neurosurgery and its permeability to brain tissue is well known.It has been speculated that mannitol not only has the effect of dehydration, reducing cerebral vascular resistance and increasing cerebral blood flow, Blood viscosity was assessed by the authors for the determination of hemorrheology.1 Of the 11 patients with intracranial aneurysms surgery, 1 g / kg of mannitol was infused intravenously at the beginning of the procedure, before and after the input Half an hour, two hours and four hours each heparinized blood samples taken at 37 ℃, followed by determination of four major factors affecting blood viscosity: 1. Plasma viscosity, 2. Hematocrit, 3. Red blood cells Aggregation and 4. Erythrocyte deformability at the same time using standard methods hematocrit,