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目的探讨胃癌手术患者抗菌药物的使用策略及其对术后感染的影响,为临床抗菌药物使用策略的制定提供参考。方法选取2009年6月-2013年6月在医院接受胃癌切除术的患者196例,随机分为观察组和对照组各98例;对照组患者在术后24h内静脉滴注头孢西丁预防感染,观察组在术前30min肌内注射头孢西丁,比较两组患者术后感染率,数据采用SPPS 17.0进行软件分析。结果患者术后感染率观察组为3.06%、对照组为15.31%,观察组术后感染率显著低于对照组(P<0.05);观察组培养出病原菌3株,耐药率为0,对照组培养出病原菌15株,耐药率为80.00%,观察组病原菌的耐药率显著低于对照组(P<0.05)。结论优化胃癌手术围手术期抗菌药物使用策略有利于降低胃癌术后感染的发生率,减少耐药菌株的产生,值得临床进一步推广应用。
Objective To investigate the strategy of using antimicrobial agents in patients with gastric cancer and its influence on postoperative infection, and to provide reference for the formulation of clinical antimicrobial agents. Methods A total of 196 patients undergoing gastric cancer resection from June 2009 to June 2013 in our hospital were randomly divided into observation group and control group with 98 cases each. Patients in the control group were given intravenous cefoxitin for infection prevention within 24 hours after operation . The observation group received intramuscular injection of cefoxitin 30 min before operation, and the infection rate was compared between the two groups. The data were analyzed by SPPS 17.0 software. Results The postoperative infection rate was 3.06% in the observation group and 15.31% in the control group. The postoperative infection rate in the observation group was significantly lower than that in the control group (P <0.05). Three strains of pathogens were cultured in the observation group, and the drug resistance rate was 0 Fifteen strains of pathogens were cultured and the drug resistance rate was 80.00%. The drug resistance rate of the pathogen in the observation group was significantly lower than that in the control group (P <0.05). Conclusion Optimizing the use of antimicrobial agents in perioperative period of gastric cancer surgery is beneficial to reduce the incidence of postoperative infection of gastric cancer and reduce the generation of drug-resistant strains. It is worth further clinical application.