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恶性胶质瘤是成人中枢神经系统中最常见的原发性脑肿瘤。即便采取最积极的综合治疗方案,仍不能阻止其快速恶性进展。目前的研究一方面关注各种异常活化的信号通路,另一方面,放、化疗抵抗的机制也被广泛探讨。信号转导和转录活化因子3(STAT3)是一个致瘤性的转录因子,涉及脑胶质瘤增殖、凋亡、血管生成以及免疫逃逸的多个关键靶基因。一些临床研究还发现STAT3的活化与放、化疗的敏感性有着密切关系。这些研究提示STAT3有望成为脑胶质瘤治疗的潜在靶标。
Glioblastoma is the most common primary brain tumor in adult central nervous system. Even the most aggressive combination of therapies can not stop its rapid progression. The current research focuses on the one hand, a variety of abnormal activation of signaling pathways, on the other hand, radiotherapy and chemotherapy mechanisms of resistance are also widely discussed. Signal Transducer and Activator of Transcription 3 (STAT3) is a tumorigenic transcription factor that is involved in multiple key target genes of glioma proliferation, apoptosis, angiogenesis and immune escape. Some clinical studies also found that the activation of STAT3 and radiotherapy and chemotherapy are closely related to the sensitivity. These studies suggest that STAT3 is expected to be a potential target for glioma therapy.