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目的:探讨兰索拉唑预防十二指肠球部溃疡复发的疗效。方法:将经4周兰索拉唑30mgqd治疗进入瘢痕期的45例十二指肠球部溃疡患者随机分入两个治疗组:组Ⅰ:兰索拉唑30mg qod维持2个月;组Ⅱ:兰索拉哇30mg qod,维持4个月。在维持治疗开始后第4、8、12个月末和出现溃疡复发症状时复查胃镜。结果:经1年追踪随访,组Ⅰ和组Ⅱ患者的溃疡一年累积复发率分别为17.4％(4/23)和18.2％(4/22),两组间差异无显著性。吸烟者的复发率高于不吸烟者。幽门螺杆菌阴性溃疡患者和阳性患者其复发率相近。结论:2个月或4个月低剂量兰索拉唑维持治疗可有效预防十二指肠球部溃疡复发。
Objective: To investigate the efficacy of lansoprazole in preventing recurrence of duodenal ulcer. METHODS: Forty-five patients with duodenal ulcer entering the scar stage treated with lansoprazole 30 mg qd for 4 weeks were randomly assigned to two treatment groups: group I: lansoprazole 30 mg qod for 2 months; group II : Lan Sora wow 30mg qod, for 4 months. Gastroscopy was reviewed at the end of the 4th, 8th, and 12th months after the treatment was started and the symptoms of ulcer recurrence were observed. Results: The cumulative recurrence rates of ulcers in group Ⅰ and group Ⅱ after one year follow-up were 17.4% (4/23) and 18.2% (4/22), respectively. There was no significant difference between the two groups. Smoker’s recurrence rate is higher than non-smoker. Helicobacter pylori negative ulcer patients and positive patients the recurrence rate was similar. Conclusion: Lansoprazole maintenance therapy at 2 months or 4 months can effectively prevent the recurrence of duodenal ulcer.