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A chloro-bridged dinuclear copper(II) complex with ligand 2-pyridylme-thylene-furfurylamine has been synthesized and characterized by single-crystal X-ray diffraction, and its inhibitory activity on xanthine oxidase (XO) was also evaluated. It crystallizes in the triclinic system, space group P1 with a=8.0441(16), b=8.5663(17), c=10.060(2), α=77.52(3), β= 72.04(3), γ=70.12(3)°, V=615.3(2)3, Z=1, Dc=1.731 g/cm3, F(000)=322, the final R= 0.0401 and wR=0.0934 for 1971 observed reflections with I > 2σ(I). X-ray analysis reveals that the Cu(II) cation is five-coordinated by two N atoms of Schiff base and three Cl anions. The C-H…Cl intermolecular and intramolecular hydrogen bonds connect the molecules to form a three-dimensional network. This copper(II) complex shows more potent inhibitory activity against XO with IC50=3.48 μM than the standard inhibitor allopurinol.
A chloro-bridged dinuclear copper (II) complex with ligand 2-pyridylme-thylene-furfurylamine has been synthesized and characterized by single-crystal X- ray diffraction, and its inhibitory activity on xanthine oxidase (XO) was also evaluated. It crystallizes in the triclinic system has space group P1 with a = 8.0441 (16), b = 8.5663 (17), c = 10.060 (2) α, α = 77.52 (3), β = 72.04 (3) °, V = 615.3 (2) 3, Z = 1, Dc = 1.731 g / cm3, F (000) = 322, and the final R = 0.0401 and wR = 0.0934 for 1971 at 971 simulated reflections with I> 2σ (I). X-ray analysis reveals that the Cu (II) cation is five-coordinated by two N atoms of Schiff base and three Cl anions. The CH ... Cl intermolecular and intramolecular hydrogen bonds connect the molecules to form a three-dimensional network. This copper (II) complex shows more potent inhibitory activity against XO with IC50 = 3.48 μM than the standard inhibitor allopurinol.