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目的:观察二甲双胍联合吡格列酮治疗2型糖尿病的临床效果。方法:随机选取2012年2月-2014年3月我院收治的2型糖尿病患者70例作为研究对象,按照数字法分为对照组(35)和观察组(35),对照组单纯给予盐酸二甲双胍片治疗,观察组在此基础上给予盐酸吡格列酮片,比较两组患者的各项血糖指标及体重变化和临床效果。结果:经临床治疗,两组患者的血糖指标和体重均获得明显改善,较之治疗前比较,P<0.05;观察组的各项血糖指标改善情况显著优于对照组,且其治疗总有效率明显高于对照组,组间差异显著,具有统计学意义(P均<0.05)。结论:二甲双胍联合吡格列酮治疗2型糖尿病疗效显著,安全性高,具有积极的临床使用和推广价值。
Objective: To observe the clinical effect of metformin combined with pioglitazone on type 2 diabetes mellitus. Methods: Seventy patients with type 2 diabetes who were admitted to our hospital from February 2012 to March 2014 were selected randomly as the control group (35) and observation group (35) according to the digital method. The control group was given metformin hydrochloride alone On the basis of this, pioglitazone hydrochloride tablets were given to the observation group. The changes of blood glucose, body weight and clinical effects were compared between the two groups. Results: After clinical treatment, the blood glucose and body weight of both groups were significantly improved, compared with before treatment, P <0.05; the improvement of various glycemic indexes in the observation group was significantly better than the control group, and the total effective rate Significantly higher than the control group, significant difference between groups, with statistical significance (P all <0.05). CONCLUSION: Metformin and pioglitazone are effective in treating type 2 diabetes mellitus with high safety and have positive clinical use and promotion value.