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为了解过敏性紫癜（ＨＳＰ）患儿糖皮质激素受体（ＧＣＲ）及Ｔ细胞亚群的改变，采用放射配基结合一点分析法，测定了患儿和健康儿童（各３５ 例）的外周血Ｔ淋巴细胞亚群及ＧＣＲ。结果：患儿外周血ＣＤ＋３ ，ＣＤ＋４ 细胞及ＣＤ＋４ ／ＣＤ＋８ 细胞比值分别为４６．０３％ ±９．４０％ ，３１．０６％ ±６．８０％ 和１．２３±０．３３，淋巴细胞ＧＣＲ值为３０６０±２１５３结合位点／细胞。健康对照儿童外周血ＣＤ＋３ ，ＣＤ＋４ 细胞及ＣＤ＋４ ／ＣＤ＋８ 细胞比值分别为５３．１１％ ±５．４０％ ， ３５．０１±４．４１％ 及１．５２±０．２６，淋巴细胞ＧＣＲ为５２１０±１６３９ 结合位点／细胞。患儿的ＣＤ＋３ ，ＣＤ＋４ 及ＣＤ＋４ ／ ＣＤ＋８ 水平较健康儿童低，ＧＣＲ水平也低于对照儿童（Ｐ＜ ０．００１），提示过敏性紫癜儿童具有免疫调节紊乱，ＧＣＲ水平减少，可能在一定程度上导致了免疫调节紊乱，从而参予了过敏性紫癜的发病。
In order to understand the changes of glucocorticoid receptor (GCR) and T cell subsets in children with Henoch-Schonlein purpura (HSP), the peripheral blood of children and healthy children (35 cases each) were determined by radioligand binding assay T lymphocyte subsets and GCR. Results: The ratios of CD + 3, CD + 4 and CD + 4 / CD + 8 in peripheral blood were 46.03% ± 9.40%, 31.06% ± 6.80% and 1.23 ± 0.33, respectively. The lymphocyte GCR 3060 ± 2153 binding sites / cell. The ratio of CD + 3, CD + 4 and CD + 4 / CD + 8 cells in peripheral blood of healthy controls were 53.11% ± 5.40%, 35.01 ± 4.41% and 1.52 ± 0.26, respectively. The GCR of lymphocytes was 5210 ± 1639 binding site / cell. Children with CD + 3, CD + 4 and CD + 4 / CD + 8 levels lower than healthy children, GCR levels are also lower than the control children (P <0.001), suggesting that children with allergic purpura immune regulation disorders, GCR levels may be reduced to some extent Leading to immune regulation disorders, which participated in the incidence of allergic purpura.