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为了评价长春新碱对周围神经系统的长期影响,作者调查了1981～1990年间用长春新碱治疗(18～24周,累积量12mg)的40例非何杰金氏淋巴瘤患者,主要询问有关神经系统疾病的症状,并在用长春新碱治疗后4～77个月(平均31个月)进行体格和以及包括振动知觉力和热分辨阈测定在内的定量感觉的检查.在27例有神经系统症状的病人中,13例在检查时仍有症状,且以感觉神经的症状和体征为主,另14例过去就有症状,停止治疗后症状持续最长时间达40个月.在检查时有无主诉的病人间无年龄的差异.有三分之二病人的反射能力正常,神经系统的远期症状并不严重.据此作者认为与长春新碱的剂量相关的长春新碱性神经病的症状和体征在很大程度上是可逆的.而且预后良好.
To assess the long-term effects of vincristine on the peripheral nervous system, the authors investigated 40 non-Hodgkin’s lymphoma patients treated with vincristine (18-24 weeks, cumulative 12 mg) between 1981 and 1990 and asked mainly about Neurological disease, and physical examination and quantitative sensory examination including vibrational sensation and thermal resolution threshold were performed 4 to 77 months (mean, 31 months) after treatment with vincristine In 27 patients who had Of the patients with neurological symptoms, 13 were still symptomatic at examination and were predominantly symptomatic and symptomatic of the sensory nerves. The other 14 patients had symptoms in the past and the symptoms last up to 40 months after treatment was stopped. There is no age difference between patients complained of when two thirds of patients with normal reflexes, neurological long-term symptoms are not serious.According to the author that the dose of vincristine vincristine neuropathy The symptoms and signs are largely reversible and the prognosis is good.