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目的了解2015年资阳市常住人口健康人群麻疹抗体水平,初步评价该人群的麻疹免疫状况。方法选择资阳市辖区常住健康人群,分2岁~、5岁~、8岁~、15岁~、20岁~共5个年龄组健康人群。以所辖雁江、简阳等4县(市、区),每个年龄组30人共600人份标本作为监测对象。采用调查问卷收集检测对象的人口学特征、麻疹患病史、含麻疹成分疫苗免疫史。采集静脉血3~5m L分离血清。使用ELISA方法进行麻疹Ig G抗体定性、定量检测分析。结果资阳市健康人群麻疹Ig G抗体定性检测阳性率95.50%,定量检测阳性率96.17%,两种方法检测麻疹Ig G抗体的差异无统计学意义(P>0.05);其中男性、女性阳性率分别为95.76%、96.53%,两者麻疹Ig G抗体差异无统计学意义(P>0.05);各年龄组阳性率分别为2岁~98.28%,20岁~100%,为最高。5岁~93.02%、8岁~96.88%、15岁~92.45为最低,各年龄组麻疹Ig G抗体差异具有统计学意义(P<0.05);具有完全保护能力的高滴度[1](≥1 000 m IU/m L)麻疹抗体个体占39.17%,其中男女(≥1 000 m IU/m L)各占37.64%,40.52%,两者间麻疹Ig G抗体差异无统计学意义(P>0.05);各年龄组(≥1 000 m IU/m L)分别占49.12%、38.33%、27.42%,30.61%、49.59%;各年龄组(≥1 000 m IU/m L)间麻疹Ig G抗体差异具有统计学意义(χ~2=20.483,df=4,P<0.05);城区、城乡结合部、乡村麻疹Ig G抗体阳性率分别为95%(190/200)、97.50%(195/200)、96.00%(192/200),三者间差异无统计学意义(P>0.05);结论四川资阳市2~岁和20岁以上健康人群的麻疹Ig G抗体水平较高,阳性率分别为98.27%和100%。5~岁(阳性率为92.96%)、15岁~(阳性率为92.45%)相对偏低,这个年龄段的麻疹Ig G抗体水平有待进一步提高。
Objective To understand the level of measles antibody in healthy population of resident population in Ziyang City in 2015 and to evaluate the measles immune status of this population initially. Methods Residents in Ziyang City were divided into two groups: healthy people of 2 years old, 5 years old, 8 years old, 15 years old, 20 years old and 5 years old. In the jurisdiction of Yanjiang, Jianyang and other 4 counties (cities, districts), 30 people in each age group a total of 600 copies of specimens as the monitoring object. A questionnaire was collected to collect the demographic characteristics of subjects, the history of measles, and the vaccine immunization history with measles components. Collect venous blood 3 ~ 5m L sera. Measles Ig G antibody using ELISA method for qualitative, quantitative detection and analysis. Results The positive rate of measles Ig G antibody in healthy population of Ziyang was 95.50%, the positive rate of quantitative detection was 96.17%. There was no significant difference between the two methods in detecting Ig G antibody of measles (P> 0.05). The positive rates of male and female were (95.76%, 96.53%). There was no significant difference in Ig G antibody between the two groups (P> 0.05). The positive rates of each group were 2 years old to 98.28% and 20 years old to 100% respectively. 5 to 93.02%, 8 to 96.88% and 15 to 92.45, respectively. The IgG antibody levels of measles in all age groups were statistically significant (P <0.05), with high titer of complete protection [1] (≥ The measles antibody population accounted for 39.17% of all cases (1 000 m IU / m L), with 37.64% (40.52%) male and female (≥1 000 m IU / m L). There was no significant difference in measles IgG antibody levels between the two groups (P> 0.05). The average age of the patients (≥1 000 m IU / m L) was 49.12%, 38.33%, 27.42%, 30.61% and 49.59% (Χ ~ 2 = 20.483, df = 4, P <0.05). The positive rates of Ig G antibody in urban area, urban-rural area and rural area were 95% (190/200) and 97.50% (195 / (P> 0.05) .Conclusion IgM antibodies against measles in 2-year-old and over 20-year-old healthy people in Ziyang are higher than those in normal population 98.27% and 100%. 5 ~ years old (positive rate of 92.96%), 15 years old (positive rate of 92.45%) is relatively low, this age group of measles Ig G antibody levels to be further improved.