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目的 通过对双原发乳腺癌的流行病学及临床和病理特点的探讨 ,找到早期诊断 ,合理治疗和改善预后的方法。方法 统计我院 195 9～ 1997年经手术和病理证实的双原发乳腺癌 97例 ,从发病率、发病年龄、间隔时间、肿瘤分期和病理、诊断和治疗、复发和转移以及生存率等方面加以分析。结果 双原发乳腺癌占同期手术治疗的乳腺癌的 2 .5 % ,高发年龄≤ 45岁 ,间隔时间为 5年 5个月。第一、二原发癌均以浸润性非特异型癌为主 ,分别为71.1%和 73.2 %。以 a 期为主 ,均为 34 .0 %。术后辅助治疗分别为 73.2 %和 88.7%。术后复发转移分别为 17.5 %和 6 7.0 %。 5、10、2 0年生存率分别为 86 .6 %、5 7.7%和 2 5 .8%。结论 双原发乳腺癌是多原发恶性肿瘤中的常见病 ,严密随诊可尽早检出第二原发癌 ,合理和积极的治疗可取得满意的效果。
Objective To find out the methods of early diagnosis, reasonable treatment and improvement of prognosis by studying the epidemiology and clinical and pathological features of dual primary breast cancer. Methods Statistical analysis of 97 primary and secondary breast cancer cases confirmed by surgery and pathology in our hospital from 195 to 1997, including morbidity, age at onset, interval, tumor stage and pathology, diagnosis and treatment, recurrence and metastasis, and survival rate Analyze it. Results Two primary breast cancers accounted for 2.5 percent of breast cancers treated during the same period, with a high age of ≤ 45 years, and the interval was 5 years and 5 months. The primary and secondary primary cancers were mainly invasive non-specific cancers, which were 71.1% and 73.2%, respectively. Mainly in period a, they are 34.0 %. Postoperative adjuvant treatment was 73.2% and 88.7%, respectively. Recurrence and metastasis after surgery were 17.5% and 67.0%, respectively. The 5-, 10-, and 20-year survival rates were 86.6%, 5.7%, and 25.8%, respectively. Conclusion Double primary breast cancer is a common disease in multiple primary malignant tumors. The second primary cancer can be detected as soon as possible after follow-up. Reasonable and positive treatment can achieve satisfactory results.