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目前降压药物治疗的原则是采用降压剂的阶段投药法,亦即依病情病期、并发症等因素的不同,有步骤地选择搭配各种降压药物,按阶段、有计划地治疗。现有的降压药物,依作用机制不同大体可分为三类:(1)利尿剂;(2)包括交感神经受体阻断剂在内的交感神经抑制剂;(3)周围血管扩张剂。在合并用药时,须先由作用缓和的药物开始,渐增添或配用其它作用较强的药物。在选择合并用药时,亦应从上列三种不用作用的药物中,各选出一种,与之搭配。亦即通常先用噻嗪类利尿剂合并β-阻滞剂,其后再加用血管扩张剂,如肼苯达嗪等。这种并用方法,通常相互副作用少,而且能增加降压效果。在不合理的并用疗法当中,最须警惕的是合并应用3种以上的交感神经抑制剂。
Currently the principle of antihypertensive drug treatment is the use of step-down drug administration method, that is, according to the disease period, complications and other factors, step by step with a variety of antihypertensive drugs, according to the stage, a planned treatment. The existing antihypertensive drugs, according to the different mechanisms of action can be broadly divided into three categories: (1) diuretics; (2) including sympathetic nerve blockers, including sympathetic nerve blockers; (3) peripheral vasodilators . In the merger medication, you must first be the role of the drug to ease, the gradual increase or use of other drugs with stronger role. In the choice of drug combination, but also from the above three kinds of non-use of drugs, each choose one, and with. That is usually first with thiazide diuretics combined with β-blockers, followed by vasodilators, such as hydralazine and so on. This combination of methods, usually less side effects, and can increase the antihypertensive effect. In the unreasonable combination therapy, the most vigilant is the combined use of more than three kinds of sympathetic nerve suppressant.