论文部分内容阅读
骨髓增生异常综合征(Myelodysplastic Syndrome,MDS)是一种恶性克隆性疾病,病变发生在造血干细胞水平,其主要特征为骨髓无效造血和病态造血。在病情发展过程中,最终有一部分患者(约20～30％)转变为急性白血病,一部分病人因骨髓造血功能衰竭导致出血或感染而死亡。人们对这种造血功能异常的疾病早有认识,从疾病的特征曾给予多种命名:如假性再生性贫血(1907年),难治性贫血(1938年),白血病前期(1953年),获得性难治性铁粒幼细胞性贫血(1956年),冒烟性白血病(1963年),白血病前期综合征(1973年),骨髓发育异常(1976年)等。自1976年以来的5年中,经大量病例的临床观察和对本病的
Myelodysplastic syndrome (Myelodysplastic Syndrome, MDS) is a malignant clonal disease that occurs at the level of hematopoietic stem cells, with the main features of myelodysplastic hematopoiesis and pathological hematopoiesis. In the course of the disease, some patients eventually (about 20 to 30%) turn to acute leukemia, and some patients die of bleeding or infection due to hematopoietic failure of bone marrow. People have long known about this disorder of hematopoietic dysfunction and have given them various names from the characteristics of the disease: such as pseudo-regenerative anemia (1907), refractory anemia (1938), pre-leukemia (1953) Obtained refractory chromogranular anemia (1956), smoky leukemia (1963), pre-leukemia (1973), myelodysplastic (1976) and so on. Five years since 1976, a large number of cases of clinical observation and the disease